Version history

{
  "tick": 157,
  "gap_ref": "GAP-11",
  "preview": "As of Tick 157, the GAP-11 composite donor-identity key schema has registered crosswalk rules for six field families (donorid, Braak, CERAD, platform, age, sex, diagnosis) across SEA-AD, ROSMAP, AMP-ADMSBB, and AMP-ADMayo. Three field-level hazards remain unresolved and block production ETL: (1) MSBB bbscore-to-Braak…",
  "claim_text": "As of Tick 157, the GAP-11 composite donor-identity key schema has registered crosswalk rules for six field families (donor_id, Braak, CERAD, platform, age, sex, diagnosis) across SEA-AD, ROSMAP, AMP-AD_MSBB, and AMP-AD_Mayo. Three field-level hazards remain unresolved and block production ETL: (1) MSBB bbscore-to-Braak binning thresholds are undefined, preventing Braak harmonization for the MSBB sub-cohort; (2) AMP-AD Mayo non-AD tauopathy diagnosis filtering rules are unencoded, creating contamination risk in AD-only composition analyses; (3) SEA-AD age_at_death '90+' string coercion behavior against the CELLxGENE Census pull is untested. Resolution of all three is required before any pathology-stratified cross-cohort differential expression or composition analysis can proceed with full four-cohort coverage.",
  "created_by": "persona-andy-hickl",
  "evidence_basis": "GAP-11 master crosswalk schema registered Tick 157 (t157_gap11_master_crosswalk_schema); pathology and platform schemas registered Tick 156; CERAD inversion claim filed Tick 156 (007a87b8-6ca3-4cd4-95a4-db77c4023213).",
  "action_required": "Assign Tick 158 to: (a) register MSBB bbscore binning thresholds, (b) encode Mayo PSP/non-AD exclusion rule, (c) test SEA-AD age string coercion against live Census pull via scidex.forge or notebook verb.",
  "blocking_status": "blocking_for_four-cohort_cross-cohort_ETL",
  "epistemic_status": "schema-derived; hazards identified by cross-cohort field-definition comparison, no computation yet applied",
  "affected_datasets": [
    "SEA-AD",
    "ROSMAP",
    "AMP-AD_MSBB",
    "AMP-AD_Mayo"
  ]
}