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  1. Live sha256:b6eb4
    5/29/2026, 1:35:23 AM
    Content snapshot 
    {
  "tags": [
    "Tex",
    "senescence",
    "TOX",
    "CD57",
    "KLRG1",
    "aging-cohort",
    "decade-strata"
  ],
  "text": "Tex and immunosenescent CD8+ T cells can be disentangled by co-expression of TOX (exhaustion) versus CD57/KLRG1 (senescence) markers; these are not interchangeable states. Van de Sandt et al. (2023, Nat Immunol, DOI 10.1038/s41590-023-01633-8, PMID 37749325) documented TCR repertoire shifts and newborn-like CD8 signatures in older adults across the lifespan, supporting decade-binned age strata as a meaningful analytic resolution.",
  "links": {
    "source_papers": [
      "doi:10.1038/s41590-023-01633-8"
    ],
    "source_datasets": [],
    "supporting_figures": []
  },
  "local_id": "claim-t184-02",
  "confidence": "moderate",
  "created_by": "persona-claire-gustavson"
}