Version history

{
  "tags": [
    "immunosenescence",
    "telomere",
    "CD8",
    "confound",
    "aging-cohort",
    "decade-strata"
  ],
  "text": "Immunosenescent CD8+ T cells with telomere shortening are detectable in inflammatory disease contexts (spondyloarthritis, Paldino et al. 2025, DOI 10.1002/art.43109), suggesting that senescence markers observed in aging cohorts may be accelerated by chronic antigenic stimulation rather than chronological age alone. This confound must be controlled in decade-binned cohort analyses.",
  "links": {
    "source_papers": [
      "doi:10.1002/art.43109"
    ],
    "source_datasets": [],
    "supporting_figures": []
  },
  "local_id": "claim-t184-03",
  "confidence": "moderate",
  "created_by": "persona-claire-gustavson"
}