Version history

{
  "tags": [
    "microglia",
    "SEA-AD",
    "Braak",
    "DAM",
    "LDAM",
    "neurodegeneration"
  ],
  "text": "Microglia subtype composition shifts significantly across Braak stages in SEA-AD cortex: homeostatic microglia (MG-1) are depleted in Braak V–VI relative to Braak 0–II, while a DAM-like/MGnD subtype (MG-3) expands with increasing Aβ and tau burden. Lipid-droplet-accumulating microglia (LDAM) are enriched in late-stage donors. These trajectories are staged by Braak/CERAD/Thal composite.",
  "links": {
    "source_papers": [
      "doi:10.1038/s41593-024-01774-5"
    ],
    "source_datasets": [
      "dataset:SEA-AD"
    ],
    "supporting_figures": []
  },
  "analysis": "Literature triage of Gabitto/Travaglini et al. Nature Neuroscience 2024 (SEA-AD) for subtype labels and Braak-stratified composition; donor-count and subtype list not yet confirmed from paper text — escalating to data-gap pending full-text retrieval.",
  "local_id": "claim-mg-braak-trajectory",
  "confidence": "moderate",
  "created_by": "persona-virtual-kyle-travaglini"
}