Version history

{
  "scope": "mouse V1 L2/3 in vivo, awake, two-photon all-optical, drifting gratings",
  "claim_text": "In mouse V1 L2/3, two-photon single-cell optogenetic activation reveals that an excitatory neuron's net influence on its neighbors is on average suppressive, with stronger suppression of neighbors having similar tuning, indicating feature-specific competition rather than amplification.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-019-0997-6",
    "claim": "In mouse V1 L2/3, two-photon single-cell optogenetic activation reveals that an excitatory neuron's net influence on its neighbors is on average suppressive, with stronger suppression of neighbors having similar tuning, indicating feature-specific competition rather than amplification.",
    "cite_key": "Chettih2019",
    "evidence": "Two-photon influence mapping: single-cell optogenetic activation of identified V1 L2/3 pyramidal neurons combined with simultaneous calcium imaging of neighbors in awake mice viewing oriented gratings; regression of influence on signal correlation, noise correlation, and distance.",
    "effect_size": "Targeted activation reduced population response to the targeted neuron’s preferred stimulus by ~2%",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 in vivo, awake, two-photon all-optical, drifting gratings",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In V1 layer 2/3, excitatory neurons on average suppressed other neurons and had a center-surround influence profile over anatomical space. A neuron’s influence on a neighbor depended on their similarity in activity. Notably, neurons suppressed activity in similarly tuned neurons more than dissimilarly tuned neurons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41593-025-02024-y"
    ],
    "effect_size_source_sentence": "Also, photostimulation reduced the population response, specifically to the targeted neuron’s preferred stimulus, by ~2%."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Targeted activation reduced population response to the targeted neuron’s preferred stimulus by ~2%",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-31f54bcea8a4"
  ],
  "source_span": "In V1 layer 2/3, excitatory neurons on average suppressed other neurons and had a center-surround influence profile over anatomical space. A neuron’s influence on a neighbor depended on their similarity in activity. Notably, neurons suppressed activity in similarly tuned neurons more than dissimilarly tuned neurons.",
  "study_system": "mouse V1 L2/3 in vivo, awake, two-photon all-optical, drifting gratings",
  "evidence_refs": [
    {
      "ref": "paper:paper-31f54bcea8a4"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon influence mapping: single-cell optogenetic activation of identified V1 L2/3 pyramidal neurons combined with simultaneous calcium imaging of neighbors in awake mice viewing oriented gratings; regression of influence on signal correlation, noise correlation, and distance.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}