In mouse V1 L2/3, two-photon single-cell optogenetic activation reveals that an…

In mouse V1 L2/3, two-photon single-cell optogenetic activation reveals that an excitatory neuron's net influence on its neighbors is on average suppressive, with stronger suppression of neighbors having similar tuning, indicating feature-specific competition rather than amplification.

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  "doi": "10.1038/s41586-019-0997-6",
  "claim": "In mouse V1 L2/3, two-photon single-cell optogenetic activation reveals that an excitatory neuron's net influence on its neighbors is on average suppressive, with stronger suppression of neighbors having similar tuning, indicating feature-specific competition rather than amplification.",
  "cite_key": "Chettih2019",
  "evidence": "Two-photon influence mapping: single-cell optogenetic activation of identified V1 L2/3 pyramidal neurons combined with simultaneous calcium imaging of neighbors in awake mice viewing oriented gratings; regression of influence on signal correlation, noise correlation, and distance.",
  "effect_size": "Targeted activation reduced population response to the targeted neuron’s preferred stimulus by ~2%",
  "text_access": "fulltext",
  "study_system": "mouse V1 L2/3 in vivo, awake, two-photon all-optical, drifting gratings",
  "argument_role": "supporting",
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  "claim_source_sentence": "In V1 layer 2/3, excitatory neurons on average suppressed other neurons and had a center-surround influence profile over anatomical space. A neuron’s influence on a neighbor depended on their similarity in activity. Notably, neurons suppressed activity in similarly tuned neurons more than dissimilarly tuned neurons.",
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    "10.1038/s41593-025-02024-y"
  ],
  "effect_size_source_sentence": "Also, photostimulation reduced the population response, specifically to the targeted neuron’s preferred stimulus, by ~2%."
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In V1 layer 2/3, excitatory neurons on average suppressed other neurons and had a center-surround influence profile over anatomical space. A neuron’s influence on a neighbor depended on their similarity in activity. Notably, neurons suppressed activity in similarly tuned neurons more than dissimilarly tuned neurons.

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Two-photon influence mapping: single-cell optogenetic activation of identified V1 L2/3 pyramidal neurons combined with simultaneous calcium imaging of neighbors in awake mice viewing oriented gratings; regression of influence on signal correlation, noise correlation, and distance.