- claim_text
In Disc1 mutant mice modeling psychiatric illness, the number of PV fast-spiking interneurons is reduced, they receive fewer excitatory inputs and form fewer release sites on targets, leading to impaired low-gamma oscillations in prelimbic cortex
- raw_fields
{
"n": 0,
"doi": "10.7554/elife.04979",
"claim": "In Disc1 mutant mice modeling psychiatric illness, the number of PV fast-spiking interneurons is reduced, they receive fewer excitatory inputs and form fewer release sites on targets, leading to impaired low-gamma oscillations in prelimbic cortex",
"evidence": "In vivo electrophysiology, histology, and computational modeling in Disc1 mutant mice",
"effect_size": "Theta and low-gamma synchrony impaired; inversely correlated with behavioral despair",
"text_access": "fulltext",
"study_system": "Disc1 mutant mouse prelimbic cortex, in vivo",
"replication_status": "single study",
"claim_source_sentence": "The number of FS-INs is reduced, they receive fewer excitatory inputs, and form fewer release sites on targets. Computational analysis indicates that weak excitatory input and inhibitory output of FS-INs may lead to impaired gamma oscillations.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Theta and low-gamma synchrony in the prelimbic cortex (PrlC) is impaired in Disc1 mice and inversely correlated with the extent of behavioural despair."
}- source_refs
[
"paper:paper-d9270b4444dd"
]
- source_span
The number of FS-INs is reduced, they receive fewer excitatory inputs, and form fewer release sites on targets. Computational analysis indicates that weak excitatory input and inhibitory output of FS-INs may lead to impaired gamma oscillations.
- evidence_refs
[
{
"ref": "paper:paper-d9270b4444dd"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}