Version history

{
  "scope": "Disc1 mutant mouse prelimbic cortex, in vivo",
  "claim_text": "In Disc1 mutant mice modeling psychiatric illness, the number of PV fast-spiking interneurons is reduced, they receive fewer excitatory inputs and form fewer release sites on targets, leading to impaired low-gamma oscillations in prelimbic cortex",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.04979",
    "claim": "In Disc1 mutant mice modeling psychiatric illness, the number of PV fast-spiking interneurons is reduced, they receive fewer excitatory inputs and form fewer release sites on targets, leading to impaired low-gamma oscillations in prelimbic cortex",
    "evidence": "In vivo electrophysiology, histology, and computational modeling in Disc1 mutant mice",
    "effect_size": "Theta and low-gamma synchrony impaired; inversely correlated with behavioral despair",
    "text_access": "fulltext",
    "study_system": "Disc1 mutant mouse prelimbic cortex, in vivo",
    "replication_status": "single study",
    "claim_source_sentence": "The number of FS-INs is reduced, they receive fewer excitatory inputs, and form fewer release sites on targets. Computational analysis indicates that weak excitatory input and inhibitory output of FS-INs may lead to impaired gamma oscillations.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Theta and low-gamma synchrony in the prelimbic cortex (PrlC) is impaired in Disc1 mice and inversely correlated with the extent of behavioural despair."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "Theta and low-gamma synchrony impaired; inversely correlated with behavioral despair",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-d9270b4444dd"
  ],
  "source_span": "The number of FS-INs is reduced, they receive fewer excitatory inputs, and form fewer release sites on targets. Computational analysis indicates that weak excitatory input and inhibitory output of FS-INs may lead to impaired gamma oscillations.",
  "study_system": "Disc1 mutant mouse prelimbic cortex, in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-d9270b4444dd"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "In vivo electrophysiology, histology, and computational modeling in Disc1 mutant mice",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "single study",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}