Version history

{
  "scope": "mouse auditory cortex layer 4 cortico-striatal pyramidal neurons",
  "claim_text": "Mouse auditory cortex layer 4 contains a previously undescribed long-range cortico-striatal (CS-L4) pyramidal cell class that receives direct thalamic input and projects to posterior striatum, contradicting the canonical view that L4 only forms local interlaminar connections; CS-L4 neurons are embedded in a thalamo→cortico(L4)→striatal feed-forward inhibitory circuit through local PV+ interneurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1738-21.2021",
    "claim": "Mouse auditory cortex layer 4 contains a previously undescribed long-range cortico-striatal (CS-L4) pyramidal cell class that receives direct thalamic input and projects to posterior striatum, contradicting the canonical view that L4 only forms local interlaminar connections; CS-L4 neurons are embedded in a thalamo→cortico(L4)→striatal feed-forward inhibitory circuit through local PV+ interneurons.",
    "cite_key": "Bertero2022",
    "evidence": "Anterograde and retrograde tracing, electrophysiology and ChR2-assisted optogenetic mapping of L4 neurons in mouse auditory cortex.",
    "effect_size": "qualitative — novel L4 long-range corticofugal cell class with thalamic input and striatal output",
    "text_access": "abstract_only",
    "study_system": "mouse auditory cortex layer 4 cortico-striatal pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs. The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — novel L4 long-range corticofugal cell class with thalamic input and striatal output",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-a5667e433556"
  ],
  "source_span": "we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs. The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons",
  "study_system": "mouse auditory cortex layer 4 cortico-striatal pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-a5667e433556"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Anterograde and retrograde tracing, electrophysiology and ChR2-assisted optogenetic mapping of L4 neurons in mouse auditory cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}