Mouse auditory cortex layer 4 contains a previously undescribed long-range cort…

Mouse auditory cortex layer 4 contains a previously undescribed long-range cortico-striatal (CS-L4) pyramidal cell class that receives direct thalamic input and projects to posterior striatum, contradicting the canonical view that L4 only forms local interlaminar connections; CS-L4 neurons are embedded in a thalamo→cortico(L4)→striatal feed-forward inhibitory circuit through local PV+ interneurons.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1738-21.2021",
  "claim": "Mouse auditory cortex layer 4 contains a previously undescribed long-range cortico-striatal (CS-L4) pyramidal cell class that receives direct thalamic input and projects to posterior striatum, contradicting the canonical view that L4 only forms local interlaminar connections; CS-L4 neurons are embedded in a thalamo→cortico(L4)→striatal feed-forward inhibitory circuit through local PV+ interneurons.",
  "cite_key": "Bertero2022",
  "evidence": "Anterograde and retrograde tracing, electrophysiology and ChR2-assisted optogenetic mapping of L4 neurons in mouse auditory cortex.",
  "effect_size": "qualitative — novel L4 long-range corticofugal cell class with thalamic input and striatal output",
  "text_access": "abstract_only",
  "study_system": "mouse auditory cortex layer 4 cortico-striatal pyramidal neurons",
  "argument_role": "supporting",
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  "claim_source_sentence": "we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs. The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex"
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  "paper:paper-a5667e433556"
]

we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs. The CS-L4 neurons are embedded in a feedforward inhibitory circuit involving local parvalbumin neurons

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