Version history

{
  "scope": "mouse hippocampal CA1 slices, VIP optogenetics + whole-cell recording",
  "claim_text": "Theta-burst stimulation of excitatory inputs to mouse CA1 oriens interneurons induces heterosynaptic, non-Hebbian inhibitory LTD at VIP-IS3→oriens-IN synapses, weakening disinhibition and increasing oriens IN excitatory/inhibitory ratio—linking theta activity to plasticity of VIP-mediated disinhibitory circuits.",
  "raw_fields": {
    "n": null,
    "doi": "10.1111/apha.70162",
    "pmid": "41549331",
    "year": "2026",
    "claim": "Theta-burst stimulation of excitatory inputs to mouse CA1 oriens interneurons induces heterosynaptic, non-Hebbian inhibitory LTD at VIP-IS3→oriens-IN synapses, weakening disinhibition and increasing oriens IN excitatory/inhibitory ratio—linking theta activity to plasticity of VIP-mediated disinhibitory circuits.",
    "pmcid": "",
    "title": "Non-Hebbian Long-Term Depression at VIP Interneuron Inputs Selectively Tunes Inhibition in Disinhibitory Circuits of Mouse Hippocampus.",
    "authors": "",
    "journal": "",
    "cite_key": "Jabonska2026",
    "evidence": "Whole-cell recordings + optogenetic VIP input activation in mouse hippocampal CA1 slices; pharmacology of L/T-type Ca channels and CB1 receptors.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "theta-burst induces iLTD at VIP→oriens IN synapses; PV/SST→Pyr synapses follow STDP",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "mouse hippocampal CA1 slices, VIP optogenetics + whole-cell recording",
    "cited_by_count": 0,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 38,
    "claim_source_sentence": "Notably, physiologically relevant theta-burst stimulation of excitatory inputs to oriens interneurons induced heterosynaptic I → I iLTD and increased the excitatory/inhibitory balance in these cells, thereby enhancing their recruitment.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "theta-burst stimulation of excitatory inputs to oriens interneurons induced heterosynaptic I → I iLTD and increased the excitatory/inhibitory balance in these cells"
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "theta-burst induces iLTD at VIP→oriens IN synapses; PV/SST→Pyr synapses follow STDP",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-435d954ea744"
  ],
  "source_span": "Notably, physiologically relevant theta-burst stimulation of excitatory inputs to oriens interneurons induced heterosynaptic I → I iLTD and increased the excitatory/inhibitory balance in these cells, thereby enhancing their recruitment.",
  "study_system": "mouse hippocampal CA1 slices, VIP optogenetics + whole-cell recording",
  "evidence_refs": [
    {
      "ref": "paper:paper-435d954ea744"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-cell recordings + optogenetic VIP input activation in mouse hippocampal CA1 slices; pharmacology of L/T-type Ca channels and CB1 receptors.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}