Theta-burst stimulation of excitatory inputs to mouse CA1 oriens interneurons i…

Theta-burst stimulation of excitatory inputs to mouse CA1 oriens interneurons induces heterosynaptic, non-Hebbian inhibitory LTD at VIP-IS3→oriens-IN synapses, weakening disinhibition and increasing oriens IN excitatory/inhibitory ratio—linking theta activity to plasticity of VIP-mediated disinhibitory circuits.

{
  "n": null,
  "doi": "10.1111/apha.70162",
  "pmid": "41549331",
  "year": "2026",
  "claim": "Theta-burst stimulation of excitatory inputs to mouse CA1 oriens interneurons induces heterosynaptic, non-Hebbian inhibitory LTD at VIP-IS3→oriens-IN synapses, weakening disinhibition and increasing oriens IN excitatory/inhibitory ratio—linking theta activity to plasticity of VIP-mediated disinhibitory circuits.",
  "pmcid": "",
  "title": "Non-Hebbian Long-Term Depression at VIP Interneuron Inputs Selectively Tunes Inhibition in Disinhibitory Circuits of Mouse Hippocampus.",
  "authors": "",
  "journal": "",
  "cite_key": "Jabonska2026",
  "evidence": "Whole-cell recordings + optogenetic VIP input activation in mouse hippocampal CA1 slices; pharmacology of L/T-type Ca channels and CB1 receptors.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "theta-burst induces iLTD at VIP→oriens IN synapses; PV/SST→Pyr synapses follow STDP",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse hippocampal CA1 slices, VIP optogenetics + whole-cell recording",
  "cited_by_count": 0,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 38,
  "claim_source_sentence": "Notably, physiologically relevant theta-burst stimulation of excitatory inputs to oriens interneurons induced heterosynaptic I → I iLTD and increased the excitatory/inhibitory balance in these cells, thereby enhancing their recruitment.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "theta-burst stimulation of excitatory inputs to oriens interneurons induced heterosynaptic I → I iLTD and increased the excitatory/inhibitory balance in these cells"
}

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]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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