Cortically evoked early excitation in the subthalamic nucleus is mediated by th…

{
  "n": 2,
  "doi": "10.1523/jneurosci.0772-20.2020",
  "claim": "Cortically evoked early excitation in the subthalamic nucleus is mediated by the glutamatergic cortico-STN hyperdirect pathway, while late excitation is mediated by the cortico-striato-GPe-STN indirect pathway.",
  "cite_key": "Polyakova2020",
  "evidence": "STN neuronal recordings were combined with electrical stimulation of motor cortices and local application of glutamate receptor antagonists in the STN, muscimol in the striatum or GPe, and gabazine in the GPe in awake monkeys to dissect the origins of biphasic excitatory responses.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Macaca fuscata, subthalamic nucleus and basal ganglia in vivo",
  "source_cluster_id": "cluster_01",
  "replication_status": "novel",
  "claim_source_sentence": "These results indicate that cortically evoked early and late excitation in the STN is mediated by the cortico-STN glutamatergic hyperdirect and the cortico-striato-GPe-STN indirect pathways, respectively.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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STN neuronal recordings were combined with electrical stimulation of motor cortices and local application of glutamate receptor antagonists in the STN, muscimol in the striatum or GPe, and gabazine in the GPe in awake monkeys to dissect the origins of biphasic excitatory responses.