In rodents, an 'open' cortico-basal ganglia loop allows limbic information from…

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scope: mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit
claim_text: In rodents, an 'open' cortico-basal ganglia loop allows limbic information from the ventral striatum to modulate motor cortex via a nigrothalamic pathway, demonstrating that the canonical parallel-loops architecture is not strictly closed.
section_id: section_01
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-01
source_kind: review_finding
source_path: evidence/section_01_evidence_package.json
source_span: While our data do demonstrate mostly closed corticobasal ganglia loops within each domain, our results confirm an open cortico-basal ganglia loop allowing a one-way interaction from limbic to motor circuitry (Figure 5U).
study_system: mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit
section_title: Introduction: Swanson's Loop Hypothesis and Its Intellectual Lineage
evidence_summary: Combined viral tracing, slice electrophysiology, and in vivo optogenetics of vStr→SNr→motor thalamus→M1 pathway in mice.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: single-study
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-01
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.7554/elife.49995",
  "claim": "In rodents, an 'open' cortico-basal ganglia loop allows limbic information from the ventral striatum to modulate motor cortex via a nigrothalamic pathway, demonstrating that the canonical parallel-loops architecture is not strictly closed.",
  "cite_key": "Aoki2019",
  "evidence": "Combined viral tracing, slice electrophysiology, and in vivo optogenetics of vStr→SNr→motor thalamus→M1 pathway in mice.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit",
  "source_cluster_id": "cluster_01",
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  "claim_source_sentence": "While our data do demonstrate mostly closed corticobasal ganglia loops within each domain, our results confirm an open cortico-basal ganglia loop allowing a one-way interaction from limbic to motor circuitry (Figure 5U).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-3023485dbad7"
]

evidence_refs

[
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source_policy

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In rodents, an 'open' cortico-basal ganglia loop allows limbic information from…

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