Version history

{
  "scope": "spiking E/I network with multiple interneurons",
  "claim_text": "A model with feedforward and feedback inhibition by PV and SST/VIP populations modulates theta-gamma cross-frequency coupling, with disinhibitory VIP recruitment shifting coupling strength.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_54",
    "doi": "10.1371/journal.pcbi.1013363",
    "pmid": "40802842",
    "year": "2025",
    "claim": "A model with feedforward and feedback inhibition by PV and SST/VIP populations modulates theta-gamma cross-frequency coupling, with disinhibitory VIP recruitment shifting coupling strength.",
    "pmcid": "PMC12393765",
    "title": "The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits.",
    "authors": "Chalkiadakis D, Sánchez-Claros J, López-Madrona VJ, Canals S, Mirasso CR.",
    "journal": "PLoS computational biology",
    "cite_key": "Chalkiadakis2025b",
    "evidence": "Spiking E/I network with separate PV (feedforward) and SST+VIP (feedback) populations; parameter sweeps quantify CFC.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "spiking E/I network with multiple interneurons",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 53,
    "claim_source_sentence": "Using previously acquired electrophysiological data from the hippocampus of rats freely navigating in a familiar environment or in a novel one, we show that CFD is dynamically regulated and linked to the frequency of the gamma band, as predicted by the model.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2023.11.006",
      "10.1101/2025.05.13.653877",
      "10.1101/2024.09.30.615819",
      "10.1016/j.neuron.2018.03.037",
      "10.1162/netn_a_00427"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-625612fd621b"
  ],
  "source_span": "Using previously acquired electrophysiological data from the hippocampus of rats freely navigating in a familiar environment or in a novel one, we show that CFD is dynamically regulated and linked to the frequency of the gamma band, as predicted by the model.",
  "study_system": "spiking E/I network with multiple interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-625612fd621b"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Spiking E/I network with separate PV (feedforward) and SST+VIP (feedback) populations; parameter sweeps quantify CFC.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}