Version history

{
  "scope": "mouse primary visual cortex (V1); two-photon optogenetic mapping with multiple Cre lines and paired-recording validation",
  "claim_text": "Two-photon optogenetic stimulation in mouse V1 confirms that L4 excitatory neurons and intra-L2/3 inputs are the most common excitatory sources to L2/3 pyramidal cells, but also reveals strong excitatory input from L5 intratelencephalic neurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.71103",
    "claim": "Two-photon optogenetic stimulation in mouse V1 confirms that L4 excitatory neurons and intra-L2/3 inputs are the most common excitatory sources to L2/3 pyramidal cells, but also reveals strong excitatory input from L5 intratelencephalic neurons.",
    "cite_key": "Hage2022",
    "evidence": "Two-photon optogenetic stimulation combined with multicellular recording across Cre lines in mouse V1.",
    "effect_size": "L4→L2/3 most common; strong L5-IT→L2/3 ascending input also present.",
    "text_access": "abstract_only",
    "study_system": "mouse primary visual cortex (V1); two-photon optogenetic mapping with multiple Cre lines and paired-recording validation",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. More surprisingly, we also observed strong excitatory connections from layer 5 intratelencephalic neurons and potent translaminar inhibition from multiple interneuron subclasses.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.xinn.2024.100735",
      "10.1016/j.neuron.2008.12.020"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L4→L2/3 most common; strong L5-IT→L2/3 ascending input also present.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-14e5fb681943"
  ],
  "source_span": "Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. More surprisingly, we also observed strong excitatory connections from layer 5 intratelencephalic neurons and potent translaminar inhibition from multiple interneuron subclasses.",
  "study_system": "mouse primary visual cortex (V1); two-photon optogenetic mapping with multiple Cre lines and paired-recording validation",
  "evidence_refs": [
    {
      "ref": "paper:paper-14e5fb681943"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon optogenetic stimulation combined with multicellular recording across Cre lines in mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}