- claim_text
Two-photon optogenetic stimulation in mouse V1 confirms that L4 excitatory neurons and intra-L2/3 inputs are the most common excitatory sources to L2/3 pyramidal cells, but also reveals strong excitatory input from L5 intratelencephalic neurons.
- raw_fields
{
"n": 0,
"doi": "10.7554/elife.71103",
"claim": "Two-photon optogenetic stimulation in mouse V1 confirms that L4 excitatory neurons and intra-L2/3 inputs are the most common excitatory sources to L2/3 pyramidal cells, but also reveals strong excitatory input from L5 intratelencephalic neurons.",
"cite_key": "Hage2022",
"evidence": "Two-photon optogenetic stimulation combined with multicellular recording across Cre lines in mouse V1.",
"effect_size": "L4→L2/3 most common; strong L5-IT→L2/3 ascending input also present.",
"text_access": "abstract_only",
"study_system": "mouse primary visual cortex (V1); two-photon optogenetic mapping with multiple Cre lines and paired-recording validation",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. More surprisingly, we also observed strong excitatory connections from layer 5 intratelencephalic neurons and potent translaminar inhibition from multiple interneuron subclasses.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1016/j.xinn.2024.100735",
"10.1016/j.neuron.2008.12.020"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-14e5fb681943"
]
- source_span
Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. More surprisingly, we also observed strong excitatory connections from layer 5 intratelencephalic neurons and potent translaminar inhibition from multiple interneuron subclasses.
- evidence_refs
[
{
"ref": "paper:paper-14e5fb681943"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}