In adult mice, PSD-95 deficiency in V1 L2/3 pyramidal neurons keeps the juvenil…

In adult mice, PSD-95 deficiency in V1 L2/3 pyramidal neurons keeps the juvenile ocular-dominance structural plasticity programme open: brief monocular deprivation doubles spine elimination in PSD-95 knockouts (especially of newly formed spines) but not in wild-type adults.

{
  "n": 0,
  "doi": "10.1073/pnas.2022701118",
  "claim": "In adult mice, PSD-95 deficiency in V1 L2/3 pyramidal neurons keeps the juvenile ocular-dominance structural plasticity programme open: brief monocular deprivation doubles spine elimination in PSD-95 knockouts (especially of newly formed spines) but not in wild-type adults.",
  "cite_key": "Yusifov2021",
  "evidence": "Two-photon imaging of L2/3 pyramidal apical spines in awake adult binocular V1 of PSD-95 KO vs WT mice showed baseline equivalence but MD-induced spine elimination only in KOs, doubling elimination of newly formed spines.",
  "effect_size": "MD doubled spine elimination in PSD-95 KO mice (vs baseline)",
  "text_access": "abstract_only",
  "study_system": "Adult mouse binocular V1 L2/3 pyramidal apical spines (in vivo two-photon, PSD-95 KO)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "However, a brief MD affected spine dynamics only in KO mice, where MD doubled spine elimination, primarily affecting newly formed spines, and caused a net reduction in spine density similar to what has been observed during jODP in WT mice.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "However, a brief MD affected spine dynamics only in KO mice, where MD doubled spine elimination, primarily affecting newly formed spines, and caused a net reduction in spine density similar to what has been observed during jODP in WT mice."
}

[
  "paper:paper-1a298f4bdf22"
]

[
  {
    "ref": "paper:paper-1a298f4bdf22"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}