Version history

{
  "scope": "adult mouse retrosplenial cortex, in vivo two-photon GCaMP imaging of L5 pyramidal soma and distal apical dendrites during BCI neurofeedback task",
  "claim_text": "In mouse retrosplenial cortex L5 pyramidal neurons, simultaneous GCaMP recording of somas and distal apical dendrites during a brain-computer interface task reveals that dendritic versus somatic signal magnitudes encode different task-related variables (reward, error) — consistent with the hypothesis that feedforward and feedback information streams are processed in distinct dendritic compartments to vectorize translaminar instructive signals.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-026-10190-7",
    "claim": "In mouse retrosplenial cortex L5 pyramidal neurons, simultaneous GCaMP recording of somas and distal apical dendrites during a brain-computer interface task reveals that dendritic versus somatic signal magnitudes encode different task-related variables (reward, error) — consistent with the hypothesis that feedforward and feedback information streams are processed in distinct dendritic compartments to vectorize translaminar instructive signals.",
    "cite_key": "Francioni2026",
    "evidence": "Mice trained on a neurofeedback BCI task; spatially intermingled populations (4–5 neurons each) of L5 pyramidal neurons in retrosplenial cortex; two-photon GCaMP imaging of somas and matched distal apical dendrites.",
    "effect_size": "Causally-defined sign-dependent putative teaching signals in apical dendrites; effect sizes in figures.",
    "text_access": "fulltext",
    "study_system": "adult mouse retrosplenial cortex, in vivo two-photon GCaMP imaging of L5 pyramidal soma and distal apical dendrites during BCI neurofeedback task",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "We observed that the relative magnitudes of somatic and dendritic signals could be predicted using the activity of the surrounding network and contained information about task-related variables that could serve as instructive signals, including reward and error.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1371/journal.pcbi.1004090"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Causally-defined sign-dependent putative teaching signals in apical dendrites; effect sizes in figures.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
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  "source_span": "We observed that the relative magnitudes of somatic and dendritic signals could be predicted using the activity of the surrounding network and contained information about task-related variables that could serve as instructive signals, including reward and error.",
  "study_system": "adult mouse retrosplenial cortex, in vivo two-photon GCaMP imaging of L5 pyramidal soma and distal apical dendrites during BCI neurofeedback task",
  "evidence_refs": [
    {
      "ref": "paper:paper-df9947b325ab"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "Mice trained on a neurofeedback BCI task; spatially intermingled populations (4–5 neurons each) of L5 pyramidal neurons in retrosplenial cortex; two-photon GCaMP imaging of somas and matched distal apical dendrites.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}