Version history

{
  "scope": "mouse cortex, inducible Mash1/Olig2-CreER fate mapping",
  "claim_text": "CGE-derived cortical interneurons begin generation at E12.5 and peak at E16.5 (about 3 days later than MGE), do not follow inside-out lamination but preferentially (75%) occupy superficial cortical layers regardless of birthdate, and constitute ~30% of all cortical interneurons across at least nine distinct subtypes; most are reelin- or VIP-positive.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.4515-09.2010",
    "claim": "CGE-derived cortical interneurons begin generation at E12.5 and peak at E16.5 (about 3 days later than MGE), do not follow inside-out lamination but preferentially (75%) occupy superficial cortical layers regardless of birthdate, and constitute ~30% of all cortical interneurons across at least nine distinct subtypes; most are reelin- or VIP-positive.",
    "title": null,
    "cite_key": "Miyoshi2010",
    "evidence": "Abstract: inducible CreER genetic fate mapping in mouse combined with electrophysiological characterization across embryonic timepoints E12.5–E16.5.",
    "effect_size": "~30% of all cortical interneurons; 75% in superficial layers; ≥9 distinct subtypes",
    "figure_data": [
      {
        "type": "lineage_proportion",
        "unit": "percent",
        "value": 30,
        "metric": "% of all cortical interneurons derived from CGE",
        "source": "Abstract / quantification",
        "context": "Mash1-CreER fate mapping in mouse cortex"
      },
      {
        "type": "lineage_proportion",
        "unit": "percent",
        "value": 75,
        "metric": "% of CGE-derived interneurons in superficial layers (II/III)",
        "source": "Quantification across cortical layers",
        "context": "Mouse cortex postnatal"
      }
    ],
    "text_access": "abstract_only",
    "study_system": "mouse cortex, inducible Mash1/Olig2-CreER fate mapping",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replicated",
    "_source_cluster_index": 12,
    "claim_source_sentence": "Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate.",
    "replication_evidence_dois": [
      "10.1093/cercor/bhq155",
      "10.1523/jneurosci.5667-03.2004",
      "10.1093/cercor/bhp310"
    ],
    "effect_size_source_sentence": "In contrast to previous estimates, CGE-derived interneurons are both considerably greater in number (∼30% of all cortical interneurons) and diversity (comprised by at least nine distinct subtypes)."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "~30% of all cortical interneurons; 75% in superficial layers; ≥9 distinct subtypes",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-2379d07993bd"
  ],
  "source_span": "Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate.",
  "study_system": "mouse cortex, inducible Mash1/Olig2-CreER fate mapping",
  "evidence_refs": [
    {
      "ref": "paper:paper-2379d07993bd"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Abstract: inducible CreER genetic fate mapping in mouse combined with electrophysiological characterization across embryonic timepoints E12.5–E16.5.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}