CGE-derived cortical interneurons begin generation at E12.5 and peak at E16.5 (…

CGE-derived cortical interneurons begin generation at E12.5 and peak at E16.5 (about 3 days later than MGE), do not follow inside-out lamination but preferentially (75%) occupy superficial cortical layers regardless of birthdate, and constitute ~30% of all cortical interneurons across at least nine distinct subtypes; most are reelin- or VIP-positive.

{
  "n": null,
  "doi": "10.1523/jneurosci.4515-09.2010",
  "claim": "CGE-derived cortical interneurons begin generation at E12.5 and peak at E16.5 (about 3 days later than MGE), do not follow inside-out lamination but preferentially (75%) occupy superficial cortical layers regardless of birthdate, and constitute ~30% of all cortical interneurons across at least nine distinct subtypes; most are reelin- or VIP-positive.",
  "title": null,
  "cite_key": "Miyoshi2010",
  "evidence": "Abstract: inducible CreER genetic fate mapping in mouse combined with electrophysiological characterization across embryonic timepoints E12.5–E16.5.",
  "effect_size": "~30% of all cortical interneurons; 75% in superficial layers; ≥9 distinct subtypes",
  "figure_data": [
    {
      "type": "lineage_proportion",
      "unit": "percent",
      "value": 30,
      "metric": "% of all cortical interneurons derived from CGE",
      "source": "Abstract / quantification",
      "context": "Mash1-CreER fate mapping in mouse cortex"
    },
    {
      "type": "lineage_proportion",
      "unit": "percent",
      "value": 75,
      "metric": "% of CGE-derived interneurons in superficial layers (II/III)",
      "source": "Quantification across cortical layers",
      "context": "Mouse cortex postnatal"
    }
  ],
  "text_access": "abstract_only",
  "study_system": "mouse cortex, inducible Mash1/Olig2-CreER fate mapping",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 12,
  "claim_source_sentence": "Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate.",
  "replication_evidence_dois": [
    "10.1093/cercor/bhq155",
    "10.1523/jneurosci.5667-03.2004",
    "10.1093/cercor/bhp310"
  ],
  "effect_size_source_sentence": "In contrast to previous estimates, CGE-derived interneurons are both considerably greater in number (∼30% of all cortical interneurons) and diversity (comprised by at least nine distinct subtypes)."
}

[
  "paper:paper-2379d07993bd"
]

Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
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