- claim_text
Patterned-optogenetics + whole-cell recordings in mouse superficial superior colliculus identified a local recurrent collicular surround-suppression mechanism that is excitatory in origin (surround-driven inhibition withdraws center excitation from recurrent excitatory circuits) — independent of cortical input, a methodological caveat for inferring cortical recurrent contributions to mouse-cortex visual responses.
- raw_fields
{
"n": 0,
"doi": "10.1371/journal.pbio.3003414",
"claim": "Patterned-optogenetics + whole-cell recordings in mouse superficial superior colliculus identified a local recurrent collicular surround-suppression mechanism that is excitatory in origin (surround-driven inhibition withdraws center excitation from recurrent excitatory circuits) — independent of cortical input, a methodological caveat for inferring cortical recurrent contributions to mouse-cortex visual responses.",
"cite_key": "Cui2025",
"evidence": "Patterned opto + whole-cell + tracing + modeling.",
"effect_size": "local collicular recurrent excitatory circuit mediates surround suppression independent of cortical input",
"text_access": "fulltext",
"study_system": "Mouse superficial SC (cortical-circuit-relevant caveat)",
"argument_role": "supporting",
"replication_status": "single-study",
"claim_source_sentence": "Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-synaptic tracing and computational modeling.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": "These findings identify a local circuit mechanism for saliency computation in the SCs, independent of cortical input."
}- source_refs
[
"paper:paper-da99a7de0519"
]
- source_span
Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-sy...
- evidence_refs
[
{
"ref": "paper:paper-da99a7de0519"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}