Version history

{
  "scope": "Mouse superficial SC (cortical-circuit-relevant caveat)",
  "claim_text": "Patterned-optogenetics + whole-cell recordings in mouse superficial superior colliculus identified a local recurrent collicular surround-suppression mechanism that is excitatory in origin (surround-driven inhibition withdraws center excitation from recurrent excitatory circuits) — independent of cortical input, a methodological caveat for inferring cortical recurrent contributions to mouse-cortex visual responses.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1371/journal.pbio.3003414",
    "claim": "Patterned-optogenetics + whole-cell recordings in mouse superficial superior colliculus identified a local recurrent collicular surround-suppression mechanism that is excitatory in origin (surround-driven inhibition withdraws center excitation from recurrent excitatory circuits) — independent of cortical input, a methodological caveat for inferring cortical recurrent contributions to mouse-cortex visual responses.",
    "cite_key": "Cui2025",
    "evidence": "Patterned opto + whole-cell + tracing + modeling.",
    "effect_size": "local collicular recurrent excitatory circuit mediates surround suppression independent of cortical input",
    "text_access": "fulltext",
    "study_system": "Mouse superficial SC (cortical-circuit-relevant caveat)",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-synaptic tracing and computational modeling.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "These findings identify a local circuit mechanism for saliency computation in the SCs, independent of cortical input."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "local collicular recurrent excitatory circuit mediates surround suppression independent of cortical input",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-da99a7de0519"
  ],
  "source_span": "Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-sy...",
  "study_system": "Mouse superficial SC (cortical-circuit-relevant caveat)",
  "evidence_refs": [
    {
      "ref": "paper:paper-da99a7de0519"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Patterned opto + whole-cell + tracing + modeling.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}