Details
- scope
- Adult mouse barrel cortex L4→L2/3 pyramidal synapses (slice after associative learning)
- claim_text
- Associative whisker classical conditioning in adult mice prevents t-LTP at barrel-cortex L4→L2/3 synapses in pyramidal neurons while leaving t-LTD intact, and MMP-9 inhibition abolishes t-LTP without affecting t-LTD.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- Learning in this paradigm practically prevented t-LTP measured in pyramidal neurons but had no effect on t-LTD.
- study_system
- Adult mouse barrel cortex L4→L2/3 pyramidal synapses (slice after associative learning)
- section_title
- 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
- evidence_summary
- Whisker-stroking/tail-shock conditioning eliminated t-LTP at L4→L2/3 synapses in barrel-cortex pyramidal cells; MMP-9 (but not MMP-3) blockade abolished t-LTP, and trained barrels showed upregulated gelatinolytic activity.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1007/s12035-016-0174-y", "claim": "Associative whisker classical conditioning in adult mice prevents t-LTP at barrel-cortex L4→L2/3 synapses in pyramidal neurons while leaving t-LTD intact, and MMP-9 inhibition abolishes t-LTP without affecting t-LTD.", "cite_key": "Lebida2017", "evidence": "Whisker-stroking/tail-shock conditioning eliminated t-LTP at L4→L2/3 synapses in barrel-cortex pyramidal cells; MMP-9 (but not MMP-3) blockade abolished t-LTP, and trained barrels showed upregulated gelatinolytic activity.", "effect_size": null, "text_access": "abstract_only", "study_system": "Adult mouse barrel cortex L4→L2/3 pyramidal synapses (slice after associative learning)", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Learning in this paradigm practically prevented t-LTP measured in pyramidal neurons but had no effect on t-LTD.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-dcc9c3699911" ]
- evidence_refs
[ { "ref": "paper:paper-dcc9c3699911" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }