Version history

{
  "scope": "rat neocortex acute slices (P16-22)",
  "claim_text": "The irregular spiking firing pattern of bipolar VIPergic neocortical interneurons is mediated by an I_D-like (Kv1-family) K+ current that can be neutralised by 4-AP, dendrotoxin-I or dendrotoxin-K to convert the cell to sustained firing.",
  "raw_fields": {
    "n": null,
    "doi": "10.1046/j.1460-9568.1998.00367.x",
    "claim": "The irregular spiking firing pattern of bipolar VIPergic neocortical interneurons is mediated by an I_D-like (Kv1-family) K+ current that can be neutralised by 4-AP, dendrotoxin-I or dendrotoxin-K to convert the cell to sustained firing.",
    "title": null,
    "cite_key": "Porter1998",
    "evidence": "rat neocortex slices P16-22, whole-cell + scRT-PCR + paired recordings + pharmacology (4-AP, dendrotoxin)",
    "effect_size": "qualitative - irregular pattern converted to sustained discharge by 4-AP and dendrotoxin",
    "text_access": "abstract_only",
    "study_system": "rat neocortex acute slices (P16-22)",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 1,
    "claim_source_sentence": "Several seconds of depolarization, micromolar concentrations of 4-aminopyridine, and nanomolar concentrations of either dendrotoxin I or K converted this irregular pattern to a sustained discharge, suggesting the involvement of an ID-like K+ current.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative - irregular pattern converted to sustained discharge by 4-AP and dendrotoxin",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-ea8f23d9476a"
  ],
  "source_span": "Several seconds of depolarization, micromolar concentrations of 4-aminopyridine, and nanomolar concentrations of either dendrotoxin I or K converted this irregular pattern to a sustained discharge, suggesting the involvement of an ID-like K+ current.",
  "study_system": "rat neocortex acute slices (P16-22)",
  "evidence_refs": [
    {
      "ref": "paper:paper-ea8f23d9476a"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "rat neocortex slices P16-22, whole-cell + scRT-PCR + paired recordings + pharmacology (4-AP, dendrotoxin)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}