Details
- scope
- rat neocortex acute slices (P16-22)
- claim_text
- The irregular spiking firing pattern of bipolar VIPergic neocortical interneurons is mediated by an I_D-like (Kv1-family) K+ current that can be neutralised by 4-AP, dendrotoxin-I or dendrotoxin-K to convert the cell to sustained firing.
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- qualitative - irregular pattern converted to sustained discharge by 4-AP and dendrotoxin
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- study_system
- rat neocortex acute slices (P16-22)
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- rat neocortex slices P16-22, whole-cell + scRT-PCR + paired recordings + pharmacology (4-AP, dendrotoxin)
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- raw_fields
{ "n": null, "doi": "10.1046/j.1460-9568.1998.00367.x", "claim": "The irregular spiking firing pattern of bipolar VIPergic neocortical interneurons is mediated by an I_D-like (Kv1-family) K+ current that can be neutralised by 4-AP, dendrotoxin-I or dendrotoxin-K to convert the cell to sustained firing.", "title": null, "cite_key": "Porter1998", "evidence": "rat neocortex slices P16-22, whole-cell + scRT-PCR + paired recordings + pharmacology (4-AP, dendrotoxin)", "effect_size": "qualitative - irregular pattern converted to sustained discharge by 4-AP and dendrotoxin", "text_access": "abstract_only", "study_system": "rat neocortex acute slices (P16-22)", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replication_unknown", "_source_cluster_index": 1, "claim_source_sentence": "Several seconds of depolarization, micromolar concentrations of 4-aminopyridine, and nanomolar concentrations of either dendrotoxin I or K converted this irregular pattern to a sustained discharge, suggesting the involvement of an ID-like K+ current.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-ea8f23d9476a" ]
- source_span
Several seconds of depolarization, micromolar concentrations of 4-aminopyridine, and nanomolar concentrations of either dendrotoxin I or K converted this irregular pattern to a sustained discharge, suggesting the involvement of an ID-like K+ current.
- evidence_refs
[ { "ref": "paper:paper-ea8f23d9476a" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }