Version history

{
  "scope": "awake mouse CA1 hippocampus, two-photon imaging + slice + model",
  "claim_text": "In awake mouse hippocampus, VIP interneuron-selective (VIP-IS) cells fire preferentially during theta-run epochs at the rising phase and peak of the theta cycle but are NOT recruited during sharp-wave ripples, contradicting model predictions for ripple recruitment.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhz334",
    "pmid": "32080739",
    "year": "2020",
    "claim": "In awake mouse hippocampus, VIP interneuron-selective (VIP-IS) cells fire preferentially during theta-run epochs at the rising phase and peak of the theta cycle but are NOT recruited during sharp-wave ripples, contradicting model predictions for ripple recruitment.",
    "pmcid": "PMC7233006",
    "title": "Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.",
    "authors": "",
    "journal": "",
    "cite_key": "Luo2020",
    "evidence": "Combined optophysiological recordings, two-photon Ca2+ imaging in awake mice, and biophysical computational modeling.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "VIP-IS cells fire at rising phase/peak of theta, absent during ripples",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "awake mouse CA1 hippocampus, two-photon imaging + slice + model",
    "cited_by_count": 49,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "contested",
    "_source_cluster_index": 6,
    "claim_source_sentence": "Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples.",
    "replication_evidence_dois": [
      "10.1101/433136",
      "10.1523/jneurosci.3813-13.2014"
    ],
    "effect_size_source_sentence": "estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP-IS cells fire at rising phase/peak of theta, absent during ripples",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-9fc387585eb3"
  ],
  "source_span": "Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples.",
  "study_system": "awake mouse CA1 hippocampus, two-photon imaging + slice + model",
  "evidence_refs": [
    {
      "ref": "paper:paper-9fc387585eb3"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Combined optophysiological recordings, two-photon Ca2+ imaging in awake mice, and biophysical computational modeling.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}