Details
- scope
- awake mouse CA1 hippocampus, two-photon imaging + slice + model
- section_id
- section_10
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- effect_size
- VIP-IS cells fire at rising phase/peak of theta, absent during ripples
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- study_system
- awake mouse CA1 hippocampus, two-photon imaging + slice + model
- section_title
- Oscillatory Dynamics and Temporal Coordination
- evidence_summary
- Combined optophysiological recordings, two-photon Ca2+ imaging in awake mice, and biophysical computational modeling.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- contested
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (6)
- claim_text
In awake mouse hippocampus, VIP interneuron-selective (VIP-IS) cells fire preferentially during theta-run epochs at the rising phase and peak of the theta cycle but are NOT recruited during sharp-wave ripples, contradicting model predictions for ripple recruitment.
- raw_fields
{ "n": null, "doi": "10.1093/cercor/bhz334", "pmid": "32080739", "year": "2020", "claim": "In awake mouse hippocampus, VIP interneuron-selective (VIP-IS) cells fire preferentially during theta-run epochs at the rising phase and peak of the theta cycle but are NOT recruited during sharp-wave ripples, contradicting model predictions for ripple recruitment.", "pmcid": "PMC7233006", "title": "Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.", "authors": "", "journal": "", "cite_key": "Luo2020", "evidence": "Combined optophysiological recordings, two-photon Ca2+ imaging in awake mice, and biophysical computational modeling.", "cluster_id": "cluster_09_oscillations", "effect_size": "VIP-IS cells fire at rising phase/peak of theta, absent during ripples", "figure_data": [], "text_access": "abstract_only", "study_system": "awake mouse CA1 hippocampus, two-photon imaging + slice + model", "cited_by_count": 49, "_source_cluster": "cluster_09_oscillations", "replication_status": "contested", "_source_cluster_index": 6, "claim_source_sentence": "Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples.", "replication_evidence_dois": [ "10.1101/433136", "10.1523/jneurosci.3813-13.2014" ], "effect_size_source_sentence": "estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples." }- source_refs
[ "paper:paper-9fc387585eb3" ]
- source_span
Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples.
- evidence_refs
[ { "ref": "paper:paper-9fc387585eb3" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }