- claim_text
Selective viral disruption of CL/CM-Pf thalamic glutamate signaling to dorsal striatum impairs motor function and slows execution of learned behaviors in mice, demonstrating that intact thalamostriatal input is required for normal motor performance.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41531-018-0060-6",
"claim": "Selective viral disruption of CL/CM-Pf thalamic glutamate signaling to dorsal striatum impairs motor function and slows execution of learned behaviors in mice, demonstrating that intact thalamostriatal input is required for normal motor performance.",
"cite_key": "Melief2018",
"evidence": "Viral-vector ablation of CL/CM-Pf glutamatergic terminals in dorsal striatum of mice with behavioral testing.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse (CAV2-based pathway-specific lesion)",
"source_cluster_id": "cluster_02",
"replication_status": "replicated",
"claim_source_sentence": "These thalamic glutamatergic neurons provide a non-cortical excitatory input to the dorsal striatum, a major projection field of dopamine neurons.",
"replication_evidence_dois": [
"10.1007/s00429-019-01967-w",
"10.3389/fnana.2023.1305500"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7cc984692d85"
]
- evidence_refs
[
{
"ref": "paper:paper-7cc984692d85"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}