Version history

{
  "scope": "mouse (CAV2-based pathway-specific lesion)",
  "claim_text": "Selective viral disruption of CL/CM-Pf thalamic glutamate signaling to dorsal striatum impairs motor function and slows execution of learned behaviors in mice, demonstrating that intact thalamostriatal input is required for normal motor performance.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41531-018-0060-6",
    "claim": "Selective viral disruption of CL/CM-Pf thalamic glutamate signaling to dorsal striatum impairs motor function and slows execution of learned behaviors in mice, demonstrating that intact thalamostriatal input is required for normal motor performance.",
    "cite_key": "Melief2018",
    "evidence": "Viral-vector ablation of CL/CM-Pf glutamatergic terminals in dorsal striatum of mice with behavioral testing.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse (CAV2-based pathway-specific lesion)",
    "source_cluster_id": "cluster_02",
    "replication_status": "replicated",
    "claim_source_sentence": "These thalamic glutamatergic neurons provide a non-cortical excitatory input to the dorsal striatum, a major projection field of dopamine neurons.",
    "replication_evidence_dois": [
      "10.1007/s00429-019-01967-w",
      "10.3389/fnana.2023.1305500"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-7cc984692d85"
  ],
  "source_span": "These thalamic glutamatergic neurons provide a non-cortical excitatory input to the dorsal striatum, a major projection field of dopamine neurons.",
  "study_system": "mouse (CAV2-based pathway-specific lesion)",
  "evidence_refs": [
    {
      "ref": "paper:paper-7cc984692d85"
    }
  ],
  "section_title": "Classical Anatomy of the Triple Descending Projection",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Viral-vector ablation of CL/CM-Pf glutamatergic terminals in dorsal striatum of mice with behavioral testing.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}