Version history

{
  "scope": "mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines",
  "claim_text": "Neuron-Derived Neurotrophic Factor (NDNF) is a highly selective marker for cortical layer-1 interneurons that is mutually exclusive with Pvalb, Sst and Vip — establishing NDNF/Lamp5 L1 cells as the principal non-VIP CGE comparator group whose dendrite-targeting connectivity and slow inhibition patterns differ from VIP-mediated disinhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2018.09.001",
    "claim": "Neuron-Derived Neurotrophic Factor (NDNF) is a highly selective marker for cortical layer-1 interneurons that is mutually exclusive with Pvalb, Sst and Vip — establishing NDNF/Lamp5 L1 cells as the principal non-VIP CGE comparator group whose dendrite-targeting connectivity and slow inhibition patterns differ from VIP-mediated disinhibition.",
    "title": null,
    "cite_key": "Abs2018",
    "evidence": "RiboTag-seq + Cre-driver lines targeting Pv, Sst, Vip, Gad2 in mouse cortex; ICC validation",
    "effect_size": "NDNF expression Gad2/[Emx1+Pv+Sst+Vip] ≥ 4 — i.e. selectively GABAergic and non-PV/SST/VIP",
    "text_access": "fulltext",
    "study_system": "mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 50,
    "claim_source_sentence": "Here, we establish Neuron-Derived Neurotrophic Factor (NDNF; Kuang et al., 2010) as a highly selective marker for L1 INs in the adult auditory and prefrontal cortex.",
    "replication_evidence_dois": [
      "10.1016/j.cell.2020.09.057",
      "10.1038/s41586-021-03950-0"
    ],
    "effect_size_source_sentence": "RiboTag-seq indicates that Ndnf-expression is highly enriched in GABAergic neurons, but not in IN subtypes that express Pv, Sst, or Vip."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "NDNF expression Gad2/[Emx1+Pv+Sst+Vip] ≥ 4 — i.e. selectively GABAergic and non-PV/SST/VIP",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-cddfd665bb4c"
  ],
  "source_span": "Here, we establish Neuron-Derived Neurotrophic Factor (NDNF; Kuang et al., 2010) as a highly selective marker for L1 INs in the adult auditory and prefrontal cortex.",
  "study_system": "mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines",
  "evidence_refs": [
    {
      "ref": "paper:paper-cddfd665bb4c"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "RiboTag-seq + Cre-driver lines targeting Pv, Sst, Vip, Gad2 in mouse cortex; ICC validation",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}