Details
- scope
- mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- NDNF expression Gad2/[Emx1+Pv+Sst+Vip] ≥ 4 — i.e. selectively GABAergic and non-PV/SST/VIP
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Here, we establish Neuron-Derived Neurotrophic Factor (NDNF; Kuang et al., 2010) as a highly selective marker for L1 INs in the adult auditory and prefrontal cortex.
- study_system
- mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- RiboTag-seq + Cre-driver lines targeting Pv, Sst, Vip, Gad2 in mouse cortex; ICC validation
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Neuron-Derived Neurotrophic Factor (NDNF) is a highly selective marker for cortical layer-1 interneurons that is mutually exclusive with Pvalb, Sst and Vip — establishing NDNF/Lamp5 L1 cells as the principal non-VIP CGE comparator group whose dendrite-targeting connectivity and slow inhibition patterns differ from VIP-mediated disinhibition.
- raw_fields
{ "n": null, "doi": "10.1016/j.neuron.2018.09.001", "claim": "Neuron-Derived Neurotrophic Factor (NDNF) is a highly selective marker for cortical layer-1 interneurons that is mutually exclusive with Pvalb, Sst and Vip — establishing NDNF/Lamp5 L1 cells as the principal non-VIP CGE comparator group whose dendrite-targeting connectivity and slow inhibition patterns differ from VIP-mediated disinhibition.", "title": null, "cite_key": "Abs2018", "evidence": "RiboTag-seq + Cre-driver lines targeting Pv, Sst, Vip, Gad2 in mouse cortex; ICC validation", "effect_size": "NDNF expression Gad2/[Emx1+Pv+Sst+Vip] ≥ 4 — i.e. selectively GABAergic and non-PV/SST/VIP", "text_access": "fulltext", "study_system": "mouse auditory + prefrontal cortex; ribosome-bound RNA-seq, Cre/Flp lines", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 50, "claim_source_sentence": "Here, we establish Neuron-Derived Neurotrophic Factor (NDNF; Kuang et al., 2010) as a highly selective marker for L1 INs in the adult auditory and prefrontal cortex.", "replication_evidence_dois": [ "10.1016/j.cell.2020.09.057", "10.1038/s41586-021-03950-0" ], "effect_size_source_sentence": "RiboTag-seq indicates that Ndnf-expression is highly enriched in GABAergic neurons, but not in IN subtypes that express Pv, Sst, or Vip." }- source_refs
[ "paper:paper-cddfd665bb4c" ]
- evidence_refs
[ { "ref": "paper:paper-cddfd665bb4c" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }