Version history

{
  "scope": "mouse hand/forelimb S1 and M1; in vivo recordings",
  "claim_text": "In vivo characterization of the mouse hand/forelimb transcortical loop shows that peripheral hand stimulation produces a short S1 barrage at ~15 ms latency followed by an M1 barrage ~10 ms later, with S1 spikes biased to middle layers (thalamocortical) and M1 spikes biased to upper layers (corticocortical) — matching the translaminar wiring diagram.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.105112",
    "claim": "In vivo characterization of the mouse hand/forelimb transcortical loop shows that peripheral hand stimulation produces a short S1 barrage at ~15 ms latency followed by an M1 barrage ~10 ms later, with S1 spikes biased to middle layers (thalamocortical) and M1 spikes biased to upper layers (corticocortical) — matching the translaminar wiring diagram.",
    "cite_key": "PinaNovo2025",
    "evidence": "In vivo silicon-probe recordings in mouse S1 and M1 during brief optogenetic photostimulation of the hand.",
    "effect_size": "S1 onset 15 ms; M1 delay 10 ms; layer biases match S1 thalamocortical and M1 corticocortical wiring.",
    "text_access": "abstract_only",
    "study_system": "mouse hand/forelimb S1 and M1; in vivo recordings",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later). … Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.7554/eLife.66836"
    ],
    "effect_size_source_sentence": "Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later)."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "S1 onset 15 ms; M1 delay 10 ms; layer biases match S1 thalamocortical and M1 corticocortical wiring.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-fb6620a1a14d"
  ],
  "source_span": "Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later). … Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity.",
  "study_system": "mouse hand/forelimb S1 and M1; in vivo recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-fb6620a1a14d"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo silicon-probe recordings in mouse S1 and M1 during brief optogenetic photostimulation of the hand.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}