In vivo characterization of the mouse hand/forelimb transcortical loop shows th…

In vivo characterization of the mouse hand/forelimb transcortical loop shows that peripheral hand stimulation produces a short S1 barrage at ~15 ms latency followed by an M1 barrage ~10 ms later, with S1 spikes biased to middle layers (thalamocortical) and M1 spikes biased to upper layers (corticocortical) — matching the translaminar wiring diagram.

{
  "n": 0,
  "doi": "10.7554/elife.105112",
  "claim": "In vivo characterization of the mouse hand/forelimb transcortical loop shows that peripheral hand stimulation produces a short S1 barrage at ~15 ms latency followed by an M1 barrage ~10 ms later, with S1 spikes biased to middle layers (thalamocortical) and M1 spikes biased to upper layers (corticocortical) — matching the translaminar wiring diagram.",
  "cite_key": "PinaNovo2025",
  "evidence": "In vivo silicon-probe recordings in mouse S1 and M1 during brief optogenetic photostimulation of the hand.",
  "effect_size": "S1 onset 15 ms; M1 delay 10 ms; layer biases match S1 thalamocortical and M1 corticocortical wiring.",
  "text_access": "abstract_only",
  "study_system": "mouse hand/forelimb S1 and M1; in vivo recordings",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later). … Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.7554/eLife.66836"
  ],
  "effect_size_source_sentence": "Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later)."
}

[
  "paper:paper-fb6620a1a14d"
]

Brief (5 ms) optogenetic photostimulation of the hand generated short (~25 ms) barrages of activity first in S1 (onset latency 15 ms) then M1 (10 ms later). … Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity.

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