Version history

{
  "scope": "mouse and human frontal cortex; snmC-seq DNA methylation",
  "claim_text": "Luo et al. (2017) used single-cell DNA methylation sequencing (snmC-seq) on >6,000 mouse and human frontal cortex nuclei to identify homologous VIP, PV, and SST inhibitory neuron subtypes between species, with methylation patterns identifying VIP-class super-enhancers around Prox1 (a CGE master regulator).",
  "raw_fields": {
    "n": 6000,
    "doi": "10.1126/science.aan3351",
    "claim": "Luo et al. (2017) used single-cell DNA methylation sequencing (snmC-seq) on >6,000 mouse and human frontal cortex nuclei to identify homologous VIP, PV, and SST inhibitory neuron subtypes between species, with methylation patterns identifying VIP-class super-enhancers around Prox1 (a CGE master regulator).",
    "title": null,
    "cite_key": "Luo2017",
    "evidence": "snmC-seq on >6,000 single nuclei (3,377 mouse + 2,805 human frontal cortex); identified 16 mouse and 21 human neuronal subpopulations; cross-species mapping aligned VIP, PV, SST homologous types; CGE-derived (VIP, NDNF) types share Prox1 super-enhancer.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse and human frontal cortex; snmC-seq DNA methylation",
    "target_section": "section_02",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 38,
    "claim_source_sentence": "Multiple human neuron clusters showed homology to mouse L5a excitatory neurons (mL5-1), L6a pyramidal neuron (mL6-2), or to VIP, PV, and SST inhibitory neurons. Super-enhancers overlap with key regulatory genes in the associated cell type, such as Prox1 in VIP+ and NDNF+ neurons."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:02e44fd7-f04b-419e-8dff-0fdaf932012b"
  ],
  "source_span": "Multiple human neuron clusters showed homology to mouse L5a excitatory neurons (mL5-1), L6a pyramidal neuron (mL6-2), or to VIP, PV, and SST inhibitory neurons. Super-enhancers overlap with key regulatory genes in the associated cell type, such as Prox1 in VIP+ and NDNF+ neurons.",
  "study_system": "mouse and human frontal cortex; snmC-seq DNA methylation",
  "evidence_refs": [
    {
      "ref": "paper:02e44fd7-f04b-419e-8dff-0fdaf932012b"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "snmC-seq on >6,000 single nuclei (3,377 mouse + 2,805 human frontal cortex); identified 16 mouse and 21 human neuronal subpopulations; cross-species mapping aligned VIP, PV, SST homologous types; CGE-derived (VIP, NDNF) types share Prox1 super-enhancer.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}