Luo et al. (2017) used single-cell DNA methylation sequencing (snmC-seq) on >6,…

Luo et al. (2017) used single-cell DNA methylation sequencing (snmC-seq) on >6,000 mouse and human frontal cortex nuclei to identify homologous VIP, PV, and SST inhibitory neuron subtypes between species, with methylation patterns identifying VIP-class super-enhancers around Prox1 (a CGE master regulator).

{
  "n": 6000,
  "doi": "10.1126/science.aan3351",
  "claim": "Luo et al. (2017) used single-cell DNA methylation sequencing (snmC-seq) on >6,000 mouse and human frontal cortex nuclei to identify homologous VIP, PV, and SST inhibitory neuron subtypes between species, with methylation patterns identifying VIP-class super-enhancers around Prox1 (a CGE master regulator).",
  "title": null,
  "cite_key": "Luo2017",
  "evidence": "snmC-seq on >6,000 single nuclei (3,377 mouse + 2,805 human frontal cortex); identified 16 mouse and 21 human neuronal subpopulations; cross-species mapping aligned VIP, PV, SST homologous types; CGE-derived (VIP, NDNF) types share Prox1 super-enhancer.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse and human frontal cortex; snmC-seq DNA methylation",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 38,
  "claim_source_sentence": "Multiple human neuron clusters showed homology to mouse L5a excitatory neurons (mL5-1), L6a pyramidal neuron (mL6-2), or to VIP, PV, and SST inhibitory neurons. Super-enhancers overlap with key regulatory genes in the associated cell type, such as Prox1 in VIP+ and NDNF+ neurons."
}

[
  "paper:02e44fd7-f04b-419e-8dff-0fdaf932012b"
]

Multiple human neuron clusters showed homology to mouse L5a excitatory neurons (mL5-1), L6a pyramidal neuron (mL6-2), or to VIP, PV, and SST inhibitory neurons. Super-enhancers overlap with key regulatory genes in the associated cell type, such as Prox1 in VIP+ and NDNF+ neurons.

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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snmC-seq on >6,000 single nuclei (3,377 mouse + 2,805 human frontal cortex); identified 16 mouse and 21 human neuronal subpopulations; cross-species mapping aligned VIP, PV, SST homologous types; CGE-derived (VIP, NDNF) types share Prox1 super-enhancer.