Version history

{
  "scope": "mouse premotor cortex (ALM); electrophysiology + optogenetic silencing during delayed-response task",
  "claim_text": "Preparatory delay activity in mouse ALM is robust to unilateral optogenetic silencing — direction-selective dynamics are restored — but selectivity does not recover after bilateral silencing, and inter-hemispheric communication via corpus callosum supports the recovery.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature17643",
    "claim": "Preparatory delay activity in mouse ALM is robust to unilateral optogenetic silencing — direction-selective dynamics are restored — but selectivity does not recover after bilateral silencing, and inter-hemispheric communication via corpus callosum supports the recovery.",
    "cite_key": "Li2016",
    "evidence": "Unilateral photoinhibition transiently abolishes ALM selectivity, which is restored within hundreds of milliseconds; bilateral silencing eliminates recovery; corpus callosum bisections show each hemisphere can maintain preparatory activity independently.",
    "effect_size": "qualitative; recovery after unilateral silencing vs. no recovery after bilateral silencing",
    "text_access": "abstract_only",
    "study_system": "mouse premotor cortex (ALM); electrophysiology + optogenetic silencing during delayed-response task",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/s41586-019-0919-7",
      "10.1016/j.cell.2021.05.026"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "effect_size": "qualitative; recovery after unilateral silencing vs. no recovery after bilateral silencing",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:e5455d9e-9c3e-450b-bddf-f40f62ee661b"
  ],
  "source_span": "We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network.",
  "study_system": "mouse premotor cortex (ALM); electrophysiology + optogenetic silencing during delayed-response task",
  "evidence_refs": [
    {
      "ref": "paper:e5455d9e-9c3e-450b-bddf-f40f62ee661b"
    }
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Unilateral photoinhibition transiently abolishes ALM selectivity, which is restored within hundreds of milliseconds; bilateral silencing eliminates recovery; corpus callosum bisections show each hemisphere can maintain preparatory activity independently.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}