Preparatory delay activity in mouse ALM is robust to unilateral optogenetic sil…

Preparatory delay activity in mouse ALM is robust to unilateral optogenetic silencing — direction-selective dynamics are restored — but selectivity does not recover after bilateral silencing, and inter-hemispheric communication via corpus callosum supports the recovery.

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  "n": 0,
  "doi": "10.1038/nature17643",
  "claim": "Preparatory delay activity in mouse ALM is robust to unilateral optogenetic silencing — direction-selective dynamics are restored — but selectivity does not recover after bilateral silencing, and inter-hemispheric communication via corpus callosum supports the recovery.",
  "cite_key": "Li2016",
  "evidence": "Unilateral photoinhibition transiently abolishes ALM selectivity, which is restored within hundreds of milliseconds; bilateral silencing eliminates recovery; corpus callosum bisections show each hemisphere can maintain preparatory activity independently.",
  "effect_size": "qualitative; recovery after unilateral silencing vs. no recovery after bilateral silencing",
  "text_access": "abstract_only",
  "study_system": "mouse premotor cortex (ALM); electrophysiology + optogenetic silencing during delayed-response task",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-019-0919-7",
    "10.1016/j.cell.2021.05.026"
  ],
  "effect_size_source_sentence": null
}

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Unilateral photoinhibition transiently abolishes ALM selectivity, which is restored within hundreds of milliseconds; bilateral silencing eliminates recovery; corpus callosum bisections show each hemisphere can maintain preparatory activity independently.