Version history

{
  "scope": "mouse, MGE (E13.5)",
  "claim_text": "Mef2c expression delineates early Pvalb-precursors among E13.5 MGE postmitotic cells and is essential for their development, identifying an autism-spectrum-disorder-associated transcription factor as a determinant of MGE-derived interneuron specification.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature25999",
    "claim": "Mef2c expression delineates early Pvalb-precursors among E13.5 MGE postmitotic cells and is essential for their development, identifying an autism-spectrum-disorder-associated transcription factor as a determinant of MGE-derived interneuron specification.",
    "title": null,
    "cite_key": "Mayer2018",
    "evidence": "scRNA-seq of E13.5 MGE plus Mef2c conditional manipulation; identified Mef2c, Erbb4, Plcxd3 as early Pvalb-precursor markers, distinct from Sst-precursors (Sst, Tspan7, Satb1).",
    "effect_size": "Mef2c required for early Pvalb-lineage development",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse, MGE (E13.5)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 82,
    "claim_source_sentence": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Examining the earliest stages, we observed a separation of Pvalb- and Sst-precursor cells within the E13.5 postmitotic populations ( Fig. 4D ), and identified transcriptomic markers that were conserved into adulthood (Early marker genes for Pvalb neurons: Mef2c, Erbb4, Plcxd3; Early marker genes for Sst neurons: Sst, Tspan7, Satb1; Fig.4E ; Extended Data Fig. 7 )."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Mef2c required for early Pvalb-lineage development",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c3e9fd7af6d3"
  ],
  "source_span": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.",
  "study_system": "mouse, MGE (E13.5)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3e9fd7af6d3"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "scRNA-seq of E13.5 MGE plus Mef2c conditional manipulation; identified Mef2c, Erbb4, Plcxd3 as early Pvalb-precursor markers, distinct from Sst-precursors (Sst, Tspan7, Satb1).",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}