Mef2c expression delineates early Pvalb-precursors among E13.5 MGE postmitotic…

Mef2c expression delineates early Pvalb-precursors among E13.5 MGE postmitotic cells and is essential for their development, identifying an autism-spectrum-disorder-associated transcription factor as a determinant of MGE-derived interneuron specification.

{
  "n": null,
  "doi": "10.1038/nature25999",
  "claim": "Mef2c expression delineates early Pvalb-precursors among E13.5 MGE postmitotic cells and is essential for their development, identifying an autism-spectrum-disorder-associated transcription factor as a determinant of MGE-derived interneuron specification.",
  "title": null,
  "cite_key": "Mayer2018",
  "evidence": "scRNA-seq of E13.5 MGE plus Mef2c conditional manipulation; identified Mef2c, Erbb4, Plcxd3 as early Pvalb-precursor markers, distinct from Sst-precursors (Sst, Tspan7, Satb1).",
  "effect_size": "Mef2c required for early Pvalb-lineage development",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "mouse, MGE (E13.5)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 82,
  "claim_source_sentence": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Examining the earliest stages, we observed a separation of Pvalb- and Sst-precursor cells within the E13.5 postmitotic populations ( Fig. 4D ), and identified transcriptomic markers that were conserved into adulthood (Early marker genes for Pvalb neurons: Mef2c, Erbb4, Plcxd3; Early marker genes for Sst neurons: Sst, Tspan7, Satb1; Fig.4E ; Extended Data Fig. 7 )."
}

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