Version history

{
  "scope": "mouse lateral visual cortex with PV manipulation",
  "claim_text": "Targeted inhibition of PV interneurons in mouse lateral visual cortex selectively attenuates cue-specific post-training reactivations and disrupts learning, implicating local inhibitory circuits in cortical replay and memory consolidation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/sciadv.adu9800",
    "claim": "Targeted inhibition of PV interneurons in mouse lateral visual cortex selectively attenuates cue-specific post-training reactivations and disrupts learning, implicating local inhibitory circuits in cortical replay and memory consolidation.",
    "cite_key": "Lensj2025",
    "evidence": "Longitudinal 2p Ca imaging + LFP + PV manipulation in mouse visual cortex across days of training.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse lateral visual cortex with PV manipulation",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Here, we use longitudinal two-photon Caimaging alongside paired LFP recordings in the hippocampus and cortex, to show that targeted manipulation of PVinhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue-elicited responses during training.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-5812d7f5c0e4"
  ],
  "source_span": "Here, we use longitudinal two-photon Caimaging alongside paired LFP recordings in the hippocampus and cortex, to show that targeted manipulation of PVinhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue-elicited responses during...",
  "study_system": "mouse lateral visual cortex with PV manipulation",
  "evidence_refs": [
    {
      "ref": "paper:paper-5812d7f5c0e4"
    }
  ],
  "section_title": "11. Physiological signature III — pattern completion, replay, and sequence generation as recurrent-circuit read-outs in mouse cortex",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Longitudinal 2p Ca imaging + LFP + PV manipulation in mouse visual cortex across days of training.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}