Targeted inhibition of PV interneurons in mouse lateral visual cortex selective…

{
  "n": null,
  "doi": "10.1126/sciadv.adu9800",
  "claim": "Targeted inhibition of PV interneurons in mouse lateral visual cortex selectively attenuates cue-specific post-training reactivations and disrupts learning, implicating local inhibitory circuits in cortical replay and memory consolidation.",
  "cite_key": "Lensj2025",
  "evidence": "Longitudinal 2p Ca imaging + LFP + PV manipulation in mouse visual cortex across days of training.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse lateral visual cortex with PV manipulation",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Here, we use longitudinal two-photon Caimaging alongside paired LFP recordings in the hippocampus and cortex, to show that targeted manipulation of PVinhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue-elicited responses during training.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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Here, we use longitudinal two-photon Caimaging alongside paired LFP recordings in the hippocampus and cortex, to show that targeted manipulation of PVinhibitory neurons in the lateral visual cortex after daily training selectively attenuates cue-specific reactivations and learning, with only minute effects on spontaneous activity and no apparent effect on normal function such as visual cue-elicited responses during...

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