Version history

{
  "scope": "mouse medial prefrontal cortex L1 interneurons and L5 PT pyramidal cells",
  "claim_text": "In mouse prefrontal cortex, ventromedial (VM) thalamus targets NDNF+ interneurons in L1a while mediodorsal (MD) thalamus drives VIP+ interneurons in L1b; NDNF+ cells inhibit the apical dendrites of layer-5 pyramidal-tract (PT) cells and selectively block VM-evoked dendritic Ca2+ spikes.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2020.10.031",
    "claim": "In mouse prefrontal cortex, ventromedial (VM) thalamus targets NDNF+ interneurons in L1a while mediodorsal (MD) thalamus drives VIP+ interneurons in L1b; NDNF+ cells inhibit the apical dendrites of layer-5 pyramidal-tract (PT) cells and selectively block VM-evoked dendritic Ca2+ spikes.",
    "cite_key": "Anastasiades2021",
    "evidence": "Anatomical tracing, slice electrophysiology, optogenetics and two-photon Ca2+ imaging of identified L1 interneurons and L5 PT cells in mouse PFC.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse medial prefrontal cortex L1 interneurons and L5 PT pyramidal cells",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We find thalamic inputs make distinct connections in L1, where VM engages neuron-derived neurotrophic factor (NDNF+) cells in L1a and MD drives vasoactive intestinal peptide (VIP+) cells in L1b... NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca signals.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-7227d2a3ed3e"
  ],
  "source_span": "We find thalamic inputs make distinct connections in L1, where VM engages neuron-derived neurotrophic factor (NDNF+) cells in L1a and MD drives vasoactive intestinal peptide (VIP+) cells in L1b... NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca signals.",
  "study_system": "mouse medial prefrontal cortex L1 interneurons and L5 PT pyramidal cells",
  "evidence_refs": [
    {
      "ref": "paper:paper-7227d2a3ed3e"
    }
  ],
  "section_title": "1. Introduction — what \"excitatory recurrence\" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Anatomical tracing, slice electrophysiology, optogenetics and two-photon Ca2+ imaging of identified L1 interneurons and L5 PT cells in mouse PFC.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}