- claim_text
In mouse prefrontal cortex, ventromedial (VM) thalamus targets NDNF+ interneurons in L1a while mediodorsal (MD) thalamus drives VIP+ interneurons in L1b; NDNF+ cells inhibit the apical dendrites of layer-5 pyramidal-tract (PT) cells and selectively block VM-evoked dendritic Ca2+ spikes.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2020.10.031",
"claim": "In mouse prefrontal cortex, ventromedial (VM) thalamus targets NDNF+ interneurons in L1a while mediodorsal (MD) thalamus drives VIP+ interneurons in L1b; NDNF+ cells inhibit the apical dendrites of layer-5 pyramidal-tract (PT) cells and selectively block VM-evoked dendritic Ca2+ spikes.",
"cite_key": "Anastasiades2021",
"evidence": "Anatomical tracing, slice electrophysiology, optogenetics and two-photon Ca2+ imaging of identified L1 interneurons and L5 PT cells in mouse PFC.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse medial prefrontal cortex L1 interneurons and L5 PT pyramidal cells",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We find thalamic inputs make distinct connections in L1, where VM engages neuron-derived neurotrophic factor (NDNF+) cells in L1a and MD drives vasoactive intestinal peptide (VIP+) cells in L1b... NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca signals.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7227d2a3ed3e"
]
- source_span
We find thalamic inputs make distinct connections in L1, where VM engages neuron-derived neurotrophic factor (NDNF+) cells in L1a and MD drives vasoactive intestinal peptide (VIP+) cells in L1b... NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca signals.
- evidence_refs
[
{
"ref": "paper:paper-7227d2a3ed3e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}