Version history

{
  "scope": "adult primate dlPFC (human, chimpanzee, macaque, marmoset)",
  "claim_text": "Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-specific somatostatin–to–tyrosine-hydroxylase switching occurs in some interneurons, indicating species-divergent inhibitory neuron molecular programs.",
  "raw_fields": {
    "n": 600000,
    "doi": "10.1126/science.abo7257",
    "claim": "Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-specific somatostatin–to–tyrosine-hydroxylase switching occurs in some interneurons, indicating species-divergent inhibitory neuron molecular programs.",
    "title": null,
    "cite_key": "Ma2022",
    "evidence": "snRNA-seq of >600,000 nuclei from adult human, chimpanzee, macaque, marmoset dlPFC.",
    "effect_size": ">600,000 single-nucleus transcriptomes profiled",
    "text_access": "abstract_only",
    "study_system": "adult primate dlPFC (human, chimpanzee, macaque, marmoset)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 49,
    "claim_source_sentence": "The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": ">600,000 single-nucleus transcriptomes profiled",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-9e019e94edbb"
  ],
  "source_span": "The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons.",
  "study_system": "adult primate dlPFC (human, chimpanzee, macaque, marmoset)",
  "evidence_refs": [
    {
      "ref": "paper:paper-9e019e94edbb"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "snRNA-seq of >600,000 nuclei from adult human, chimpanzee, macaque, marmoset dlPFC.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}