Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-s…

Details

scope: adult primate dlPFC (human, chimpanzee, macaque, marmoset)
claim_text: Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-specific somatostatin–to–tyrosine-hydroxylase switching occurs in some interneurons, indicating species-divergent inhibitory neuron molecular programs.
section_id: section_03
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
effect_size: >600,000 single-nucleus transcriptomes profiled
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-03-development
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons.
study_system: adult primate dlPFC (human, chimpanzee, macaque, marmoset)
section_title: Developmental Origins and Postnatal Maturation
evidence_summary: snRNA-seq of >600,000 nuclei from adult human, chimpanzee, macaque, marmoset dlPFC.
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-03-development
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (4)

raw_fields

{
  "n": 600000,
  "doi": "10.1126/science.abo7257",
  "claim": "Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-specific somatostatin–to–tyrosine-hydroxylase switching occurs in some interneurons, indicating species-divergent inhibitory neuron molecular programs.",
  "title": null,
  "cite_key": "Ma2022",
  "evidence": "snRNA-seq of >600,000 nuclei from adult human, chimpanzee, macaque, marmoset dlPFC.",
  "effect_size": ">600,000 single-nucleus transcriptomes profiled",
  "text_access": "abstract_only",
  "study_system": "adult primate dlPFC (human, chimpanzee, macaque, marmoset)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 49,
  "claim_source_sentence": "The latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine production in certain interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC."
}

source_refs

[
  "paper:paper-9e019e94edbb"
]

evidence_refs

[
  {
    "ref": "paper:paper-9e019e94edbb"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

Adult primate dorsolateral PFC has largely conserved cell subtypes, but human-s…

Details

Replication

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