Version history

{
  "scope": "mouse",
  "claim_text": "Integration of hunger and hormonal state gates infant-directed aggression",
  "raw_fields": {
    "n": 9,
    "doi": "10.1038/s41586-025-09651-2",
    "claim": "Integration of hunger and hormonal state gates infant-directed aggression",
    "cite_key": "Cao2025",
    "evidence": "fulltext_body",
    "effect_size": "Fig. 1 Arc AgRP →MPOA projections mediate hunger-induced, pup-directed aggression. a , Schematic of the switch to pup-directed aggression induced by food deprivation (FD). b , Percentage of Agg + mice",
    "text_access": "fulltext",
    "study_system": "mouse",
    "source_cluster_id": "cluster_08",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Scale bars, 200 µm. f , Optogenetic stimulation paradigm to assess food intake. g , Correlation between food intake and pup attack latency in mice with optogenetic stimulation of Arc AgRP →MPOA projections (linear regression, R 2 = 0.784; P = 0.046, n = 5 mice). h , Latency of food intake during continuous stimulation of Arc AgRP →MPOA and Arc AgRP →PVH projections ( n = 4 (MPOA), 4 (PVH) mice). i,j , Effect of optogenetically activating Arc AgRP →MPOA projections ( i , 1-h pre-stim, n = 5 mice) on 1-h food consumption in sated mice, and negative controls ( j , Agrp-Cre mice injected with AAV-DIO-EYFP, n = 6 mice). k,l , Effect of optogenetically activating Arc AgRP →LPOA ( k , n = 6 mice) or Arc AgRP →PVH ( l , n = 5 mice) projections on 1-h food consumption in sated mice. m , Pup attack latency after chemogenetic activation of Arc AgRP neurons (Gq), optogenetic stimulation of Arc AgRP →MPOA projections (Opto, 30-min pre stimulation), and food deprivation ( n (left to right) = 7, 5 and 39 mice).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Fig. 1 Arc AgRP →MPOA projections mediate hunger-induced, pup-directed aggression. a , Schematic of the switch to pup-directed aggression induced by food deprivation (FD). b , Percentage of Agg + mice as a function of FD duration (refed for 1 or 2 h; each point represents a cohort of n = 9–10 mice)."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "effect_size": "Fig. 1 Arc AgRP →MPOA projections mediate hunger-induced, pup-directed aggression. a , Schematic of the switch to pup-directed aggression induced by food deprivation (FD). b , Percentage of Agg + mice",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-eadbc14cd435"
  ],
  "source_span": "Scale bars, 200 µm. f , Optogenetic stimulation paradigm to assess food intake. g , Correlation between food intake and pup attack latency in mice with optogenetic stimulation of Arc AgRP →MPOA projections (linear regression, R 2 = 0.784; P = 0.046, n = 5 mice). h , Latency of food intake during continuous stimulation of Arc AgRP →MPOA and Arc AgRP →PVH projections ( n = 4 (MPOA), 4 (PVH) mice). i,j , Effect of opto...",
  "study_system": "mouse",
  "evidence_refs": [
    {
      "ref": "paper:paper-eadbc14cd435"
    }
  ],
  "section_title": "The Hypothalamic Extension: Loops for Motivated Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "fulltext_body",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}