Integration of hunger and hormonal state gates infant-directed aggression

{
  "n": 9,
  "doi": "10.1038/s41586-025-09651-2",
  "claim": "Integration of hunger and hormonal state gates infant-directed aggression",
  "cite_key": "Cao2025",
  "evidence": "fulltext_body",
  "effect_size": "Fig. 1 Arc AgRP →MPOA projections mediate hunger-induced, pup-directed aggression. a , Schematic of the switch to pup-directed aggression induced by food deprivation (FD). b , Percentage of Agg + mice",
  "text_access": "fulltext",
  "study_system": "mouse",
  "source_cluster_id": "cluster_08",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Scale bars, 200 µm. f , Optogenetic stimulation paradigm to assess food intake. g , Correlation between food intake and pup attack latency in mice with optogenetic stimulation of Arc AgRP →MPOA projections (linear regression, R 2 = 0.784; P = 0.046, n = 5 mice). h , Latency of food intake during continuous stimulation of Arc AgRP →MPOA and Arc AgRP →PVH projections ( n = 4 (MPOA), 4 (PVH) mice). i,j , Effect of optogenetically activating Arc AgRP →MPOA projections ( i , 1-h pre-stim, n = 5 mice) on 1-h food consumption in sated mice, and negative controls ( j , Agrp-Cre mice injected with AAV-DIO-EYFP, n = 6 mice). k,l , Effect of optogenetically activating Arc AgRP →LPOA ( k , n = 6 mice) or Arc AgRP →PVH ( l , n = 5 mice) projections on 1-h food consumption in sated mice. m , Pup attack latency after chemogenetic activation of Arc AgRP neurons (Gq), optogenetic stimulation of Arc AgRP →MPOA projections (Opto, 30-min pre stimulation), and food deprivation ( n (left to right) = 7, 5 and 39 mice).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Fig. 1 Arc AgRP →MPOA projections mediate hunger-induced, pup-directed aggression. a , Schematic of the switch to pup-directed aggression induced by food deprivation (FD). b , Percentage of Agg + mice as a function of FD duration (refed for 1 or 2 h; each point represents a cohort of n = 9–10 mice)."
}

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]

Scale bars, 200 µm. f , Optogenetic stimulation paradigm to assess food intake. g , Correlation between food intake and pup attack latency in mice with optogenetic stimulation of Arc AgRP →MPOA projections (linear regression, R 2 = 0.784; P = 0.046, n = 5 mice). h , Latency of food intake during continuous stimulation of Arc AgRP →MPOA and Arc AgRP →PVH projections ( n = 4 (MPOA), 4 (PVH) mice). i,j , Effect of opto...

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