Version history

{
  "scope": "Awake mouse V1, all-optical + Neuropixels",
  "claim_text": "Combining multi-Neuropixels, mesoscale two-photon calcium imaging, and two-photon holographic optogenetics in mouse V1 with illusory contour stimuli identified a subset of 'IC-encoder' neurons whose targeted holographic photoactivation recreated the V1 illusory-contour representation in the absence of any visual stimulus — direct causal evidence for recurrent pattern-completion circuits in mouse cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-025-02055-5",
    "claim": "Combining multi-Neuropixels, mesoscale two-photon calcium imaging, and two-photon holographic optogenetics in mouse V1 with illusory contour stimuli identified a subset of 'IC-encoder' neurons whose targeted holographic photoactivation recreated the V1 illusory-contour representation in the absence of any visual stimulus — direct causal evidence for recurrent pattern-completion circuits in mouse cortex.",
    "cite_key": "Shin2025b",
    "evidence": "Multi-Neuropixels + 2P imaging + holographic optogenetics; activation-only recreation of perceptual representation.",
    "effect_size": "holographic activation of IC-encoders recreates V1 illusory-contour representation without visual stimulus",
    "text_access": "fulltext",
    "study_system": "Awake mouse V1, all-optical + Neuropixels",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "We discovered a specialized subset of neurons in primary visual cortex (V1) that respond emergently to illusory bars but not to component image segments. Selective holographic photoactivation of these 'IC-encoders' recreated the visual representation of ICs in V1 in the absence of any visual stimulus.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Selective holographic photoactivation of these 'IC-encoders' recreated the visual representation of ICs in V1 in the absence of any visual stimulus."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": "holographic activation of IC-encoders recreates V1 illusory-contour representation without visual stimulus",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-d021eac95dc2"
  ],
  "source_span": "We discovered a specialized subset of neurons in primary visual cortex (V1) that respond emergently to illusory bars but not to component image segments. Selective holographic photoactivation of these 'IC-encoders' recreated the visual representation of ICs in V1 in the absence of any visual stimulus.",
  "study_system": "Awake mouse V1, all-optical + Neuropixels",
  "evidence_refs": [
    {
      "ref": "paper:paper-d021eac95dc2"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Multi-Neuropixels + 2P imaging + holographic optogenetics; activation-only recreation of perceptual representation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}