- claim_text
Diphtheria-toxin ablation of NPY/AgRP neurons in adult mice produces severe hypophagia and loss of body weight, demonstrating that AGRP neurons are necessary for normal feeding in the adult animal — directly conflicting with the developmental compensation seen when these neurons are removed neonatally.
- raw_fields
{
"n": null,
"doi": "10.1126/science.1115524",
"claim": "Diphtheria-toxin ablation of NPY/AgRP neurons in adult mice produces severe hypophagia and loss of body weight, demonstrating that AGRP neurons are necessary for normal feeding in the adult animal — directly conflicting with the developmental compensation seen when these neurons are removed neonatally.",
"cite_key": "Luquet2005",
"evidence": "abstract_only",
"effect_size": null,
"text_access": "abstract",
"study_system": "mouse (adult genetic ablation)",
"source_cluster_id": "cluster_08",
"replication_status": "unreplicated",
"claim_source_sentence": "To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria toxin.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-1fb7df45b557"
]
- evidence_refs
[
{
"ref": "paper:paper-1fb7df45b557"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}